Dziko limodzi nkhondo imodzi
─Mgwirizano wapadziko lonse lapansi kuti apange gulu lapadziko lonse lapansi lomwe likugwirizana ndi vuto la COVID-19
Mliri wa coronavirus womwe ukufalikira padziko lonse lapansi wadzetsa vuto la mliri wapadziko lonse wa COVID-19.Coronavirus yatsopano ilibe malire, palibe dziko lomwe lidzapulumutsidwe kunkhondo iyi yolimbana ndi COVID-19.Pothana ndi mliri wapadziko lonse lapansi wa COVID-19, Liming Bio-Products Corp ikupereka thandizo lothandizira moyo wamagulu athu padziko lonse lapansi.
Dziko lathu likukumana ndi vuto lomwe silinachitikepo m'mbiri ya mliri wa coronavirus wa 2019 (COVID-19).Mpaka pano, palibe mankhwala ogwira mtima omwe alipo ochizira matendawa.Komabe, kuyezetsa matenda ambiri apangidwa kuti azindikire COVID-19.Mayesowa amatengera njira zamamolekyu kapena serological kuti azindikire ma nucleic acid enieni kapena ma antibody biomarkers.Popeza COVID-19 yafika pachiwopsezo cha mliri, kuzindikira msanga kwa kachilombo ka coronavirus ndikofunikira pakuwunika kufalikira kwa kachilomboka komanso kukhala nako, koma kuyesa kwabwino kogwiritsa ntchito konsekonse sikunapezeke.Tiyenera kudziwa kuti ndi mayeso ati omwe angagwiritsidwe ntchito powunika, kuzindikira, ndikuwunika matenda a COVID-19, komanso zomwe angakwanitse.Ndikofunikira kwambiri momwe mungagwiritsire ntchito bwino zida zasayansi izi ndikuthandizira kuzindikira ndikuwongolera kutuluka kwa matenda omwe akufalikira mwachangu komanso oopsa.
Cholinga cha kuzindikira kwa buku la coronavirus ndikuzindikira ngati munthu yemwe ali ndi kachilombo ka COVID-19 kapena wonyamula asymptotic yemwe angafalitse kachilomboka mwakachetechete, kuti apereke chidziwitso chofunikira chowongolera posankha chithandizo chamankhwala.Kafukufuku wam'mbuyomu wasonyeza kuti 70% ya zisankho zachipatala zimadalira zotsatira zoyesa.Pamene njira zodziwira zosiyanasiyana zikugwiritsidwa ntchito, zofunikira za zida zodziwira zomwe zimagwiritsidwa ntchito ndizosiyana.
Chithunzi 1
Chithunzi 1:Chithunzi chomwe chikuwonetsa magawo ofunikira amtundu wa biomarker wanthawi zonse wa matenda a COVID-19.X-axis imasonyeza kuchuluka kwa masiku a matenda, ndipo Y-axis imasonyeza kuchuluka kwa ma virus, ndende ya ma antigen, ndi kuchuluka kwa ma antibodies mu nthawi zosiyanasiyana.Antibody imayimira ma antibodies a IgM ndi IgG.Onse RT-PCR ndi kuzindikira kwa antigen amagwiritsidwa ntchito kuti azindikire kupezeka kapena kusapezeka kwa coronavirus yatsopano, womwe ndi umboni wachindunji wozindikira odwala msanga.Pasanathe sabata imodzi mutatenga kachilombo ka HIV, kuzindikira kwa PCR, kapena kuzindikira kwa antigen kumakondedwa.Pambuyo pa matenda atsopano a coronavirus kwa masiku pafupifupi 7, anti anti IgM motsutsana ndi coronavirus yatsopanoyo yawonjezeka pang'onopang'ono m'magazi a wodwalayo, koma nthawi yakukhalapo ndi yochepa, ndipo ndende yake imachepa msanga.Mosiyana ndi izi, antibody ya IgG yolimbana ndi kachilomboka imawonekera pambuyo pake, nthawi zambiri pakadutsa masiku 14 kachilomboka katenga kachilomboka.Kukhazikika kwa IgG kumawonjezeka pang'onopang'ono, ndipo kumapitilira nthawi yayitali m'magazi.Chifukwa chake, ngati IgM ipezeka m'magazi a wodwalayo, zikutanthauza kuti kachilomboka katenga kachilomboka, chomwe ndi chizindikiro choyambirira cha matenda.IgG antibody ikapezeka m'magazi a wodwalayo, zikutanthauza kuti kachilomboka kakhalapo kwakanthawi.Amatchedwanso matenda mochedwa kapena matenda am'mbuyomu.Nthawi zambiri zimawoneka mwa odwala omwe ali mu gawo lochira.
Ma biomarkers a novel coronavirus
Coronavirus yatsopano ndi kachilombo ka RNA, komwe kamapangidwa ndi mapuloteni ndi nucleic acid.Kachilomboka kamalowa m'thupi la munthu (anthu), kulowa m'maselo kudzera m'malo omwe amamangirira cholandilira ACE2, ndikubwerezanso m'maselo omwe abwera nawo, zomwe zimapangitsa kuti chitetezo chamthupi cha munthu chiyankhe kwa omwe abwera kunja ndikupanga ma antibodies enieni.Chifukwa chake, ma vial nucleic acids ndi ma antigen, ndi ma antibodies enieni olimbana ndi coronavirus yatsopano atha kugwiritsidwa ntchito ngati zolembera zapadera kuti azindikire coronavirus yatsopano.Pozindikira ma nucleic acid, ukadaulo wa RT-PCR ndi womwe umagwiritsidwa ntchito kwambiri, pomwe njira za serological zimagwiritsidwa ntchito pozindikira ma antibodies enieni a coronavirus.Pakadali pano, pali njira zingapo zoyesera zomwe tingasankhe zoyezetsa matenda a COVID-19 [1].
Mfundo zoyambirira za njira zazikulu zoyesera za coronavirus yatsopano
Mayeso ambiri oyezera matenda a COVID_19 akupezeka pakadali pano, ndipo zida zoyezera zambiri zikuvomerezedwa ndi chilolezo chogwiritsa ntchito mwadzidzidzi tsiku lililonse.Ngakhale mayeso atsopanowa akubwera ndi mayina ndi mawonekedwe osiyanasiyana, mayeso onse a COVID_19 amadalira matekinoloje awiri akuluakulu: nucleic acid kuzindikira kwa ma virus a RNA ndi ma serological immunoassays omwe amazindikira ma antibodies enieni (IgM ndi IgG).
01. Kuzindikira kwa nucleic acid
Reverse transcription-polymerase chain reaction (RT-PCR), loop-mediated isothermal amplification (LAMP), ndi kutsatira m'badwo wotsatira (NGS) ndi njira zodziwika bwino za nucleic acid zodziwira novel coronavirus RNA.RT-PCR ndiye mtundu woyamba woyeserera wa COVID-19, wolimbikitsidwa ndi World Health Organisation (WHO) ndi US Center for Disease Control and Prevention (CDC).
02.Kuzindikira ma antibody a serological
Antibody ndi mapuloteni oteteza omwe amapangidwa m'thupi la munthu poyankha matenda a virus.IgM ndi mtundu wakale wa antibody pomwe IgG ndi mtundu wina wamtsogolo.Sampuli ya seramu kapena plasma nthawi zambiri imawunikiridwa ngati pali mitundu ina ya IgM ndi IgG ya anti-antibody kuti aunike magawo owopsa komanso ochiritsira a matenda a COVID-19.Njira zodziwira zotengera ma antibody izi ndi monga colloidal gold immunochromatography assay, latex kapena fluorescent microsphere immunochromatography, enzyme-linked immunosorbent assay (ELISA), ndi chemiluminescence assay.
03.Kuzindikira kwa ma antigen
Antigen ndi kapangidwe ka kachilombo komwe kamadziwika ndi thupi la munthu komwe kamayambitsa chitetezo chamthupi kupanga ma antibodies kuti achotse kachilomboka m'magazi ndi minofu.Antigen ya virus yomwe ilipo pa kachilomboka imatha kuyang'aniridwa ndikuzindikiridwa pogwiritsa ntchito immunoassay.Monga ma virus RNA, ma virus antigens amapezekanso m'mapapo a anthu omwe ali ndi kachilombo ndipo amatha kugwiritsidwa ntchito pozindikira matenda a COVID-19.Choncho, nthawi zambiri amalangizidwa kuti atole zitsanzo za m'mwamba monga malovu, nasopharyngeal ndi oropharyngeal swabs, chifuwa chachikulu, bronchoalveolar lavage fluid(BALF) poyesa antigen koyamba.
Kusankha njira zoyesera za coronavirus yatsopano
Kusankha njira yoyesera kumaphatikizapo zinthu zambiri, kuphatikiza kakhazikitsidwe kachipatala, kuwongolera khalidwe, nthawi yosinthira, ndalama zoyesera, njira zosonkhanitsira zitsanzo, zofunikira zaukadaulo wa ogwira ntchito mu labotale, zofunikira za malo ndi zida.Kuzindikira kwa ma nucleic acid kapena ma virus antigen ndikupereka umboni wachindunji wa kukhalapo kwa ma virus ndikutsimikizira kupezeka kwa matenda atsopano a coronavirus.Ngakhale pali njira zambiri zodziwira ma antigen, kukhudzika kwawo kwa coronavirus yatsopano ndikotsika poyerekeza ndi kukulitsa kwa RT-PCR.Kuyeza ma antibodies ndi kuzindikira kwa ma antibodies omwe amapangidwa m'thupi la munthu, komwe kumachedwa ndipo nthawi zambiri sangagwiritsidwe ntchito kuti azindikire msanga panthawi yovuta ya kachilombo ka HIV.Mawonekedwe azachipatala ozindikiritsa ntchito amatha kukhala osiyanasiyana, ndipo malo osonkhanitsira zitsanzo angakhalenso osiyana.Kuti azindikire ma virus nucleic acids ndi ma antigen, chitsanzocho chiyenera kusonkhanitsidwa m'malo opumira momwe kachilomboka kamapezeka, monga ma nasopharyngeal swabs, oropharyngeal swabs, sputum, kapena bronchoalveolar lavage fluid (BALF).Kuti muzindikire motengera ma antibodies, magazi amayenera kusonkhanitsidwa ndikuwunikiridwa kuti adziwe ngati alipo enieni odana ndi ma virus (IgM/IgG).Komabe, zotsatira za mayeso a antibody ndi nucleic acid zimatha kuthandizirana.Mwachitsanzo, zotulukapo zoyezetsa zitakhala kuti nucleic acid-negative, IgM-negative koma IgG-positive, zotsatirazi zikuwonetsa kuti wodwalayo sakunyamula kachilomboka, koma wachira ku matenda atsopano a coronavirus.[2]
Ubwino ndi kuipa kwa mayeso atsopano a coronavirus
Mu Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version7) (Yotulutsidwa ndi National Health Commission & State Administration of Traditional Chinese Medicine pa Marichi 3, 2020), kuyesa kwa nucleic acid kumagwiritsidwa ntchito ngati njira yodziwika bwino ya golide pakuzindikiritsa bukuli. matenda a coronavirus, pomwe kuyezetsa ma antibody kumaganiziridwanso ngati njira imodzi yotsimikizira za matendawa.
Zotsatira za pathogenic ndi serological
(1) Zomwe zimayambitsa matenda: Novel coronavirus nucleic acid imatha kuzindikirika mu ma nasopharyngeal swabs, sputum, kutulutsa m'munsi mwa kupuma, magazi, ndowe ndi zitsanzo zina pogwiritsa ntchito njira za RT-PCRand/kapena NGS.Ndi zolondola kwambiri ngati zitsanzo zimachokera ku m'munsi kupuma thirakiti (sputum kapena mpweya thirakiti m'zigawo).Zitsanzozi ziyenera kutumizidwa kuti zikayesedwe mwamsanga mukatha kusonkhanitsa.
(2) Zotsatira za serological: NCP virus yeniyeni IgM imakhala yodziwika masiku 3-5 pambuyo poyambira;IgG imafika pakuwonjezeka kwapang'onopang'ono ka 4 panthawi yakuchira poyerekeza ndi gawo lowopsa.
Komabe, kusankha njira zoyezera kumadalira komwe kuli, malamulo azachipatala, komanso mayendedwe azachipatala.Ku USA, NIH idapereka Malangizo a Chithandizo cha Coronavirus Disease 2019 (COVID-19) (Sitengo Yasinthidwa: Epulo 21,2020 ) ndipo FDA idapereka Ndondomeko Yoyezetsa Matenda a Matenda a Coronavirus-2019 pa Nthawi Yangozi Yaumoyo Pagulu (yomwe idaperekedwa pa Marichi 16,2020 ), momwe kuyesa kwa serological kwa ma antibodies a IgM/IgG osankhidwa ngati kuyesa kowunika.
Nucleic Acid Kuzindikira Njira
RT_PCR ndi kuyesa kovutirapo kwa nucleic acid komwe kumapangidwira kuti muwone ngati kachilombo ka corona RNA kakupezeka kapena ayi.Zotsatira zoyezetsa za PCR zikutanthauza kupezeka kwa buku la coronavirus RNA mu zitsanzo kutsimikizira matenda a COVID-19.Zotsatira zoyipa za PCR sizitanthauza kusakhalapo kwa kachilombo ka HIV chifukwa zitha kukhudzidwa ndi mtundu wocheperako kapena nthawi ya matenda panthawi yomwe wachira, ndi zina.Ngakhale RT-PCR ndi mayeso ovuta kwambiri, ili ndi zovuta zingapo.Kuyesa kwa RT-PCR kumatha kukhala kovutirapo komanso kuwononga nthawi, kutengera mtundu wapamwamba wa zitsanzo.Izi zitha kukhala zovuta chifukwa kuchuluka kwa ma virus a RNA sikungosiyana kwambiri pakati pa odwala osiyanasiyana komanso kumatha kusiyanasiyana mkati mwa wodwala yemweyo malinga ndi nthawi yomwe chitsanzocho chimasonkhanitsidwa komanso magawo omwe ali ndi kachilomboka kapena kuyamba kwa zizindikiro zachipatala.Kuzindikira coronavirus yatsopano kumafuna zitsanzo zapamwamba kwambiri zomwe zimakhala ndi RNA yokwanira ya virus.
Mayeso a RT-PCR atha kupereka zotsatira zolakwika (zabodza) kwa odwala ena omwe ali ndi kachilombo ka COVID-19.Monga tikudziwira, malo akuluakulu omwe ali ndi kachilombo ka coronavirus amapezeka m'mapapo ndi m'munsi mwa kupuma, monga alveoli ndi bronchi.Choncho, sputum chitsanzo kuchokera ku chifuwa chachikulu kapena bronchoalveolar lavage fluid (BALF) amaonedwa kuti ali ndi chidziwitso chapamwamba kwambiri pozindikira tizilombo.Komabe, muzochita zachipatala, zitsanzo nthawi zambiri zimasonkhanitsidwa kuchokera kumtunda wapamwamba wa kupuma pogwiritsa ntchito swabs za nasopharyngeal kapena oropharyngeal.Kutolera zitsanzozi sikovuta kwa odwala komanso kumafuna anthu ophunzitsidwa bwino.Kuti sampuli zisakhale zovuta kapena zosavuta, nthawi zina odwala amatha kupatsidwa swab pakamwa ndikuwalola kuti atenge chitsanzo kuchokera ku buccal mucosa kapena kupukuta lilime.Popanda ma virus a RNA okwanira, RT-qPCR imatha kubweza zotsatira zoyesa zabodza.M'chigawo cha Hubei, China, kukhudzika kwa RT-PCR pakuzindikira koyamba kudanenedwa pafupifupi 30% -50%, pafupifupi 40%.Kuchulukitsidwa kwabodza kunayambika chifukwa chosakwanira sampuli.
Kuphatikiza apo, kuyesa kwa RT-PCR kumafuna ogwira ntchito ophunzitsidwa bwino kuti achite masitepe ovuta a RNA ndi njira yokulitsira PCR.Pamafunikanso mlingo wapamwamba wa chitetezo cha biosafety, malo apadera a labotale, ndi zida za PCR zenizeni.Ku China, kuyesa kwa RT-PCR pozindikira kuti ali ndi COVID-19 kuyenera kuchitidwa m'ma laboratories amtundu 2 (BSL-2), ndi chitetezo cha ogwira ntchito pogwiritsa ntchito biosafety level 3 (BSL-3).Pazifukwa izi, kuyambira koyambirira kwa Januware mpaka koyambirira kwa February 2020, mphamvu ya labotale yaku China Wuhan CDC idangotha kuzindikira mazana angapo patsiku.Nthawi zambiri, izi sizingakhale vuto poyesa matenda ena opatsirana.Komabe, polimbana ndi mliri wapadziko lonse lapansi monga COVID-19 wokhala ndi anthu mamiliyoni ambiri kuti ayesedwe, RT-PCR imakhala nkhani yovuta chifukwa cha zofunikira zake pama laboratories apadera kapena zida zaukadaulo.Zoyipa izi zitha kuchepetsa RT-PCR kuti igwiritsidwe ntchito ngati chida chowunikira, komanso zingayambitse kuchedwa kwa malipoti azotsatira zoyesa.
Njira yodziwira ma antibodies a serological
Ndi kupita patsogolo kwa matendawa, makamaka m'magawo apakati komanso mochedwa, kuchuluka kwa ma antibodies kumakwera kwambiri.Kafukufuku yemwe adachitika ku Wuhan Central South Hospital adawonetsa kuti kuchuluka kwa ma anti-antibody kumatha kufika kupitilira 90% sabata yachitatu ya matenda a COVID-19.Komanso, antibody ndi chida chachitetezo cha chitetezo chamunthu motsutsana ndi buku la coronavirus.Kuyesa kwa antibody kumapereka maubwino angapo kuposa RT-PCR.Choyamba, ma serological antibody amayesa mosavuta komanso mwachangu.Mayeso a antibody lateral flow atha kugwiritsidwa ntchito popereka chisamaliro kuti apereke zotsatira pakadutsa mphindi 15.Kachiwiri, chandamale chomwe chadziwika ndi mayeso a serological ndi antibody, yomwe imadziwika kuti ndiyokhazikika kwambiri kuposa ma virus a RNA.Potolera, kunyamula, kusungirako ndi kuyesa, zoyeserera zoyeserera za antibody nthawi zambiri zimakhala zokhazikika kuposa zitsanzo za RT-PCR.Chachitatu, chifukwa antibody imagawidwa mofanana m'magazi, pali kusiyana kocheperako poyerekeza ndi kuyesa kwa nucleic acid.Voliyumu yachitsanzo yofunikira pakuyezetsa ma antibody ndiyocheperako.Mwachitsanzo, ma microlita 10 a magazi obaya chala ndi okwanira kuti agwiritsidwe ntchito poyezetsa ma antibody lateral flow flow.
Nthawi zambiri, kuyesa kwa antibody kumasankhidwa ngati chida chothandizira kuzindikira kwa ma nucleic acid kuti apititse patsogolo kuzindikira kwa coronavirus yatsopano panthawi ya matenda.Kuyeza kwa antibody kukagwiritsidwa ntchito limodzi ndi kuyesa kwa nucleic acid, kumatha kukulitsa kulondola kwa kuyesa kwa COVID19 pochepetsa zotsatira zabodza komanso zabodza.Kalozera waposachedwa samalimbikitsa kugwiritsa ntchito mitundu iwiri yoyesera padera ngati njira yodziwira yokha koma iyenera kugwiritsidwa ntchito ngati mawonekedwe ophatikizidwa.[2]
Chithunzi 2:Kutanthauzira kolondola kwa ma nucleic acid ndi mayeso a antibody kumabweretsa kuzindikirika kwa matenda atsopano a coronavirus
Chithunzi 3:Liming Bio-Products Co., Ltd. - Novel coronavirus IgM/IgG antibody yapawiri yoyeserera mwachangu (StrongStep®SARS-CoV-2 IgM/IgG Antibody Rapid Test, Latex Immunochromatography)
Chithunzi 4:Liming Bio-Products Co., Ltd. - StrongStep®Novel Coronavirus (SARS-CoV-2) Multiplex Real-Time PCR kit (kuzindikira majini atatu, njira yofufuzira fulorosenti).
Zindikirani:Zida za PCR zomverera kwambiri, zokonzeka kugwiritsa ntchito zimapezeka mumtundu wa lyophilized (njira yowumitsa zowuma) kuti zisungidwe kwa nthawi yayitali.Chombocho chikhoza kunyamulidwa ndikusungidwa kutentha kwa chipinda ndipo chimakhala chokhazikika kwa chaka chimodzi.Chubu chilichonse cha premix chimakhala ndi ma reagents ofunikira pakukulitsa kwa PCR, kuphatikiza Reverse-transcriptase, Taq polymerase, primers, probes, ndi magawo a dNTPs. pa chipangizo cha PCR kuti muyambe kukulitsa.
Poyankha kufalikira kwa buku la coronavirus, Liming Bio-Products Co., Ltd. yagwira ntchito mwachangu kupanga zida ziwiri zowunikira kuti ma laboratories azachipatala komanso aboma athe kuzindikira matenda a COVID-19 mwachangu.Zidazi ndizoyenera kuti zigwiritsidwe ntchito pakuwunika kwakukulu m'maiko ndi madera omwe mliri waposachedwa wa coronavirus ukufalikira mwachangu, komanso popereka matenda ndikutsimikizira kuti ali ndi kachilombo ka COVID-19.Zidazi ndizogwiritsidwa ntchito pokhapokha pa Pre-notified Emergency Use Authorization (PEUA).Kuyesa kumangoperekedwa ku ma laboratories omwe ali ndi ziphaso pansi pa malamulo a maboma adziko kapena amdera lanu.
Njira yodziwira ma antigen
1. Kuzindikira kwa ma virus kumayikidwa m'gulu lomwelo la kuzindikira mwachindunji monga nucleic acid kuzindikira.Njira zodziwira mwachindunji izi zimayang'ana umboni wa tizilombo toyambitsa matenda m'chitsanzocho ndipo zitha kugwiritsidwa ntchito potsimikizira matenda.Komabe, kupanga zida zodziwira ma antigen kumafuna mtundu wapamwamba wa ma antibodies a monoclonal okhala ndi mgwirizano wamphamvu komanso kukhudzika kwakukulu komwe kumatha kuzindikira ndikugwira ma virus oyambitsa matenda.Nthawi zambiri zimatenga miyezi isanu ndi umodzi kuti musankhe ndikukonza anti-monoclonal antibody yoyenera kugwiritsidwa ntchito pokonzekera zida zodziwira ma antigen.
2. Pakadali pano, ma reagents ozindikira mwachindunji buku la coronavirus akadali pansi pa kafukufuku ndi chitukuko.Chifukwa chake, palibe zida zodziwira ma antigen zomwe zatsimikiziridwa ndichipatala komanso zogulitsa.Ngakhale kuti poyamba zidanenedwa kuti kampani yodziwira matenda ku Shenzhen yapanga zida zodziwira antigen ndikuyesedwa kuchipatala ku Spain, kudalirika kwa kuyesa ndi kulondola sikungathe kutsimikiziridwa chifukwa cha kukhalapo kwa nkhani za khalidwe la reagent.Mpaka pano, NMPA (yomwe kale inali China FDA) sinavomereze zida zilizonse zodziwira ma antigen kuti zigwiritsidwe ntchito pachipatala pano.Pomaliza, njira zosiyanasiyana zodziwira zapangidwa.Njira iliyonse ili ndi ubwino ndi malire ake.Zotsatira za njira zosiyanasiyana zingagwiritsidwe ntchito potsimikizira ndi kukwaniritsa.
3. Kupanga zida zoyesera za COVID-19 kumadalira kwambiri kukhathamiritsa panthawi ya kafukufuku ndi chitukuko.Malingaliro a kampani Liming Bio-Product Co., Ltd.zida zoyesera zimafunikira kuti zikwaniritse zopanga zokhazikika komanso zowongolera kuti zitsimikizire kuti zimapereka magwiridwe antchito apamwamba komanso osasinthika.Asayansi ku Liming Bio-Product Co., Ltd. ali ndi zaka zopitilira makumi awiri pakupanga, kuyesa, ndi kukhathamiritsa zida zowunikira mu vitro kuti zitsimikizire kuti magwiridwe antchito apamwamba kwambiri pakuwunika kowunika.
Munthawi ya Mliri wa COVID-19, boma la China lidayang'anizana ndi kufunikira kwakukulu kwa zida zopewera miliri m'malo omwe ali padziko lonse lapansi.Pa Epulo 5, pamsonkhano wa atolankhani wa State Council Joint Prevention and Control Mechanism "Kulimbikitsa Ubwino Woyang'anira Zida Zamankhwala ndi Kuwongolera Dongosolo la Msika", Jiang Fan, woyang'anira woyamba wa dipatimenti ya Zamalonda Zakunja mu Unduna wa Zachuma. of Commerce, adati, "Kenako, tiyang'ana zoyesayesa zathu pazigawo ziwiri, choyamba, kufulumizitsa chithandizo chamankhwala ambiri ofunikira padziko lonse lapansi, komanso, kuwongolera kuwongolera, kuwongolera, ndi kasamalidwe kazinthu. Tithandizanso China poyankha limodzi ku mliri wapadziko lonse lapansi ndikumanga gulu lomwe lili ndi tsogolo logawana la anthu.
Chithunzi 5:Buku la Liming Bio-Products Co., Ltd. lolemba buku la coronavirus lapeza satifiketi yolembetsa ku EU CE.
Satifiketi yaulemu
Houshenshan
Chithunzi 6. Liming Bio-Products Co., Ltd. idathandizira Wuhan Vulcan(HouShenShan) Mountain Hospital kuti alimbane ndi mliri wa COVID-19 ndipo adapatsidwa satifiketi yaulemu ya Wuhan Red Cross.Chipatala cha Wuhan Vulcan Mountain ndiye chipatala chodziwika bwino kwambiri ku China chomwe chimagwira ntchito zochizira odwala kwambiri a COVID - 19.
Pamene mliri watsopano wa coronavirus ukupitilira kufalikira padziko lonse lapansi, Nanjing Liming Bio-Products Co., Ltd. Ikupita patsogolo kuthandiza ndi kuthandiza anthu padziko lonse lapansi ndi umisiri watsopano kuti athane ndi chiwopsezo chomwe sichinachitikepo padziko lonse lapansi.Kuyesa mwachangu matenda a COVID-19 ndi gawo lofunikira pothana ndi chiwopsezochi.Tikupitiriza kuthandizira kwambiri popereka njira zodziwira matenda apamwamba m'manja mwa ogwira ntchito yachipatala kutsogolo kuti anthu athe kulandira zotsatira zoyesa zomwe akufunikira.Zoyeserera za Liming Bio-products Co., Ltd. polimbana ndi mliri wa COVID-19 ndikupereka umisiri wathu, zomwe takumana nazo, komanso ukadaulo wathu kumayiko akunja kuti amange gulu lapadziko lonse lapansi lamtsogolo.
Dinani Kwanthawi yayitali ~ Jambulani ndi Kutitsatira
Imelo: sales@limingbio.com
Webusayiti: https://limingbio.com
Nthawi yotumiza: May-01-2020
